Currently, the SHBG test is not performed frequently or routinely. In many cases, health practitioners feel that the total testosterone , and perhaps free testosterone (as measured by a method called equilibrium dialysis), provides sufficient information. SHBG is ordered primarily when the total testosterone results do not seem to be consistent with clinical signs and symptoms , such as infertility, decreased sex drive, and erectile dysfunction in men or infertility , irregular menstrual periods, and excess facial and body hair in women.
An increased focus on protecting the skin from sun damage and a change from an outdoor lifestyle to an indoor lifestyle in recent generations has led to a serious problem with vitamin D deficiency in many developed parts of the world. Too little vitamin D means the bones will not be able to grow strong, leading to problems like rickets for children or osteoporosis for adults. Due to the weakening of bones, individuals with low vitamin D levels are more prone to falling. Low vitamin D levels can also cause a poorly functioning immune system, cardiovascular disease, depression, development of diabetes, and multiple sclerosis. It has also been linked to certain types of cancer.
It was decades later that the secret behind this spectacular success became known. The East German Sports Federation had, with the help of the Stasi, used Performance Enhancing Drugs or PEDs to ensure that their athletes gained international recognition by winning the Olympic events. This systematic plan had been initiated in 1974 as a means to guarantee international glory through the achievement of gold medals at the prestigious sporting event. Oral- Turinabol , a testosterone derivative was used extensively to improve muscle mass and cut down recovery time. This allowed the German athletes to train harder and longer than other world athletes.