Steroid dose cns lymphoma

1 mg/kg IV every 8 to 12 hours for 1 to 5 days has been studied in premature and term neonates (combined n from 3 studies = 89, gestational age 23 to 40 weeks). An initial loading dose of 2 mg/kg IV was used in 1 retrospective study and another prospective, observational study used a higher maintenance dose of 3 to 6 mg/kg/day IV divided 2 to 4 times daily in a small number of patients (n = 5) with severe capillary leak syndrome and/or previous steroid treatment. In the largest prospective, randomized, placebo controlled study (n = 48, gestational age to weeks), patients receiving hydrocortisone 1 mg/kg IV every 8 hours for 5 days required significantly less vasopressor support (lower doses of dopamine and dobutamine, shorter duration of vasopressor therapy, and fewer patients requiring more than 1 vasopressor) compared to patients receiving placebo. The trend of the average mean arterial blood pressure (MAP) was also significantly higher in patients receiving hydrocortisone compared to patients receiving placebo.

pancreatitis / Delayed / 0-
toxic epidermal necrolysis / Delayed / 0-
exfoliative dermatitis / Delayed / 0-
erythema multiforme / Delayed / 0-
Stevens-Johnson syndrome / Delayed / 0-
AV block / Early / 0-
bradycardia / Rapid / 0-
vasculitis / Delayed / 0-
anaphylactoid reactions / Rapid / 0-
interstitial nephritis / Delayed / 0-
agranulocytosis / Delayed / 0-
hemolytic anemia / Delayed / Incidence not known
aplastic anemia / Delayed / Incidence not known
pancytopenia / Delayed / Incidence not known
atrophic gastritis / Delayed / Incidence not known

Steroid dose cns lymphoma

steroid dose cns lymphoma

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