In 2011, close to 37,000 Americans are projected to be diagnosed with oral or pharyngeal cancer. 66% of the time, these will be found as late stage three and four disease. It will cause over 8,000 deaths. Of those 37,000 newly diagnosed individuals, only slightly more than half will be alive in five years. Similar survival estimates are reported from other countries. For example, five-year relative survival for oral cavity cancer patients in Germany is about 55%.  Survival rates of patients diagnosed with oral cancer have not significantly improved in decades. The death rate for oral cancer is higher than that of cervical cancer, Hodgkin's lymphoma, laryngeal cancer, cancer of the testes, endocrine system cancers such as thyroid, and skin cancer (malignant melanoma). If the definition of oral cancer is expanded to include cancer of the larynx, for which the risk factors are the same, the numbers of diagnosed cases grow to approximately 50,000 individuals, and 13,500 deaths per year in the .. Worldwide, the problem is much greater, with over 640,000 new cases being found each year.