DNP is one of if not the most powerful fat burner in history. This compound will see fat, pure body fat melt off the individual’s frame rapidly and abundantly. Further, once the fat is lost it will be very easy to maintain the now lower body fat percentage. This compound literally attacks and destroys fat cells. Consider twenty pounds of pure fat loss in only a few weeks. For that matter consider only half that amount and already you have an extremely appealing fat loss medication. No one can deny DNP is powerfully effective, so effective it’s seemingly magical when we consider the fat loss potential. However, we cannot consider the fat loss potential without recognizing the risks. DNP truly is poison, and it will claim lives. Granted, some will get away with use, this is simply the way many things work in life, but many will not. Even if you follow the guidelines about staying cool and keep your dose at a low to moderate level the risk is still there, you may die.
A 21-year-old Korean female presented with primary amenorrhea and sexual infantilism, and intermittent hypokalemic episodes. Laboratory test was consistent with hypergonadotropic hypogonadism. The karyotype was 46,XX. Genomic DNA was extracted from peripheral blood leukocytes. All the eight exons of the CYP17A1 gene including flanking regions of introns were amplified by PCR. The mutations of the CYP17A1 gene were detected by direct sequencing. A compound heterozygous mutation was identified; one allele had a missense mutation of >T (), which was reported previously and induced the complete loss of both 17α-hydroxylase/17,20-lyase activity. This mutation has been known to be one of the common mutation types in East Asia. The other allele had a novel 1-bp deletion causing frameshift, premature termination codon () and induced truncated enzymes.
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