There were 91 pediatric subjects aged 2 months to 15 years in the first trial described above. Clinical efficacy rates at end of therapy in the evaluable populations were 78% for Mupirocin ointment (n = 42) and 36% for vehicle placebo (n = 49). In the second trial described above, all subjects were pediatric except 2 adults in the group receiving Mupirocin ointment. The age range of the pediatric subjects was 7 months to 13 years. The clinical efficacy rate for Mupirocin ointment (n = 27) was 96%, and for erythromycin it was unchanged (%).
The Malathion of greater than pharmaceutical-grade purity used in Malathion lotion has not been tested for genotoxicity. The technicalgrade Malathion (95% pure) was found to be negative in Salmonella typhimurium , equivocally positive in the mouse lymphoma cell assay, and positive in in vitro chromosomal aberration and sister chromatid exchange assays. Fifteen separate in vitro gene mutation studies with Malathion of unknown purity have reported negative results, while three studies reported Malathion to be mutagenic in bacterial cells. Both technical grade (94–%) and purified (98-99%) Malathion have been reported to cause chromosomal aberrations and sister chromatid exchanges in vitro in human and hamster cell lines. In vivo chromosomal aberration and micronucleus studies of technical-grade Malathion are reported to be positive, whereas an in vivo chromosomal aberration study of >99% pure Malathion was reported to be negative.
Hydrofilia Fluid Body Cream (Lierac) is a good moisturizer for very dry, keratotic skin. The formulation rubs in well, making it suitable for use on various body sites, including the hands, feet, and neck. With urea, mineral oil, glycerin, dimethicone, and vitamin E, it contains both emollients and humectants. Often applied topically as an anti-aging therapy, topical vitamin E is also an anti-inflammatory antioxidant. 4 Urea has concentration-dependent keratolytic effects. These desquamating properties may provide a smoother skin surface feel and possibly facilitate the delivery of other topical agents. Urea is associated with decreased transepidermal water loss and some protective effects against known skin irritants. 22