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The treatments used to manage patients with calciphylaxis can be divided into medical and surgical therapies (Table 4).2,3,6,8-- 10,12 Often, these therapies are used in tandem. Medical therapies consist of phosphate binders, low-phosphate diet, reduced calcium in the dialysate (for patients undergoing dialysis), antibiotics for secondary infection, and ,3,8,9 Diphosphonates may be used with patients at risk for calciphylaxis and have been shown to reduce its In addition, avoidance of challenging agents is important to reduce the incidence of calciphylaxis.