RAD 140 : Testolone studies are still being produced, but it has been known to have equal potency and effectiveness to that of LGD4033. Dosages ranged between 20mg to 30 mg per 24-36 hours for maximum skeletal muscle hypertrophy. Safe durations for research have been tolerated for up to 12 weeks, however, developing trials may indicate tolerance for up to 24 weeks. It is important to note that RAD140 systematically regulates the neuroexcitatory amino acid Kainate which activates glutamate receptors in the brain. Kainate acid’s role in neuronal cell death (specifically in the hippocampus) has been shown to be a primary contributor to Alzheimer’s disease. RAD140 has demonstrated positive results in the prevention of Kainate acid production and medical based research published by The Endocrine Society suggests RAD140 can improve brain health through neuroprotective properties in as little as 13 days (Jayaraman, 2014). This characteristic of nonsteroidal SARMs is not added in the General Benefits section of this article because it is exclusive only to RAD140.
The side effects of SARMS (selective androgen receptor modulators) are small therefore are not an issue not unless high dosages of SARMS are used for a long time. When used for more than 4 weeks in large doses, SARMS will become a real issue. When you have used it for a long time, you will be affected by gynecomastia, the development of male breasts. Long term use of SARMS among women will cause Virilization, which is the development of male characteristics. In extreme cases, Virilization symptoms will cause infertility in women since it will disrupt the menses of extreme female users. Other Virilization characteristics include development of the Adam's apple and the deepening of the voice. Non-target tissues like the sebaceous glands and the sexual organs will be affected by SARMS and side effects like testicular atrophy and acne will accompany any Virilization and gynecomastia. For those who have oily skin, acne will definitely be worse for them.
Not shortly after Roger Maris record was broken, another baseball player, Jason Giambi and various other athletes were either suspected of, or proven to have, taken anabolic steroids. Again, Congress convened a hearing, and just as they did the first time in 1990, they did not determine that steroids were a danger, but rather that the danger was more in protecting professional sports organizations. The updated statute has been updated to proscribe pro-hormones also The definition of an anabolic steroid as defined currently in the United States under (41)(A) is that "anabolic steroid" means any drug or hormonal substance, chemically and pharmacologically related to testosterone (other than estrogens , progestins, corticosteroids, and dehydroepiandrosterone (7).