The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany,    for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.  Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years.  Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.