Antenatal steroids dose

Dexamethasone and betamethasone are the corticosteroids used for the purpose although the former is recommended over the latter based on its efficacy, safety, wide availability, and low cost [9] in spite of some counter-logic. [10] Betamethasone, on the other hand, is preferred over dexamethasone because it is thought to have better prophylaxis of brain softening of premature fetus. [11] They are used with the intention to help the lungs of a premature fetus develop before the fetus comes out. [12] They are given when the fetus is expected to be delivered within 24 to 48 hours. Treatment consists of 2 doses of 12 mg of betamethasone given intramuscularly 24 hours apart or 4 doses of 6 mg of dexamethasone given intramuscularly 12 hours apart. Optimal benefit begins 24 hours after initiation of therapy and lasts 7 days. [13] [14] Antenatal steroids are currently used up to 36 weeks in some parts of the world obstetric practice. [15]

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:   13 Years to 55 Years   (Child, Adult) Sexes Eligible for Study:   Female Accepts Healthy Volunteers:   No Sampling Method:   Non-Probability Sample Study Population pregnant women preterm premature rupture of membranes All ethnic backgrounds Criteria Inclusion Criteria:

Treatment with antenatal corticosteroids does not increase the risk of chorioamnionitis ( RR , 95% CI to ; participants = 5546; studies = 15; moderate-quality evidence) or endometritis ( RR , 95% CI to ; participants = 4030; studies = 10; Tau² = , I² = 28%; moderate-quality). No increased risk in maternal death was observed. However, the data on maternal death is based on data from a single trial with two deaths; four other trials reporting maternal death had zero events (participants = 3392; studies = 5; moderate-quality).

REFERENCES:
Committee Opinion Committee on Obstetric Practice Number 210, October 1998 Antenatal Corticosteroid Therapy for Fetal Maturation
2. NIH Consensus Statement Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes1994 Feb 28-Mar 2;12(2):1-24
3. Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM. Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome. Am J Obstet Gynecol 131:358,1978. MEDLINE
4. Morrison JC, Schneider JM, Whybrew WD, Bucovaz ET. Effect of corticosteroids and Fetomaternal disorders on the L:S ratio. Obstet Gynecol 56:583, 1980 MEDLINE Please review the Disclaimer before using this site. Copyright © 2000-2008 by Focus Information Technology.
All rights reserved.
Created: 11/30/2002
Update: 11/30/2002
Update: 4/15/2008

Antenatal steroids dose

antenatal steroids dose

REFERENCES:
Committee Opinion Committee on Obstetric Practice Number 210, October 1998 Antenatal Corticosteroid Therapy for Fetal Maturation
2. NIH Consensus Statement Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes1994 Feb 28-Mar 2;12(2):1-24
3. Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM. Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome. Am J Obstet Gynecol 131:358,1978. MEDLINE
4. Morrison JC, Schneider JM, Whybrew WD, Bucovaz ET. Effect of corticosteroids and Fetomaternal disorders on the L:S ratio. Obstet Gynecol 56:583, 1980 MEDLINE Please review the Disclaimer before using this site. Copyright © 2000-2008 by Focus Information Technology.
All rights reserved.
Created: 11/30/2002
Update: 11/30/2002
Update: 4/15/2008

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